5-lipoxygenase knockout mice exhibit a resistance to acute pancreatitis induced by cerulein
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چکیده
منابع مشابه
Protective effect of Tribulus terrestris fruit extract on cerulein-induced acute pancreatitis in mice
Objective: Antioxidant, anti-inflammatory, analgesic and antimicrobial activities of Tribulus terrestris (T. terrestris) could be helpful in the treatment of acute pancreatitis; thus, this study was designed to investigate the effects of T. terrestris on cerulein-induced acute pancreatitis in mice. Materials and Methods: Three doses (100, 200 and 400 mg/kg) of T. terrestris hydro-alcoholic extr...
متن کاملPossible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice.
The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the cerulein-induced hyperenzymemia was attenuated in mice pretreated with p-CPA, a 5-HT depletor, it was exaggerated by the preferential 5-HT2A a...
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It has been shown that Smad3 exerts both tumor-suppressive and -promoting roles. To evaluate the role of Smad3 in skin carcinogenesis in vivo, we applied a chemical skin carcinogenesis protocol to Smad3 knockout mice (Smad3 / and Smad3 / ) and wild-type littermates (Smad3 / ). Smad3 / mice exhibited reduced papilloma formation in comparison with Smad3 / mice and did not develop any squamous cel...
متن کاملSmad3 knockout mice exhibit a resistance to skin chemical carcinogenesis.
It has been shown that Smad3 exerts both tumor-suppressive and -promoting roles. To evaluate the role of Smad3 in skin carcinogenesis in vivo, we applied a chemical skin carcinogenesis protocol to Smad3 knockout mice (Smad3(-/-) and Smad3(+/-)) and wild-type littermates (Smad3(+/+)). Smad3(-/-) mice exhibited reduced papilloma formation in comparison with Smad3(+/+) mice and did not develop any...
متن کاملpossible beneficial effects of lithium chloride on cerulein-induced acute pancreatitis in mice
one of the most important and serious disorders of gastrointestinal tract is acute pancreatitis which in severe form is associated with high mortality rate particularly in the presence of systemic inflammatory response and multiple organ failure. apoptosis linked to oxidative stress has been shown in the pancreas of the patients with acute pancreatitis. lithium, one of the most effective drugs ...
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ژورنال
عنوان ژورنال: Immunology
سال: 2003
ISSN: 0019-2805,1365-2567
DOI: 10.1046/j.1365-2567.2003.01715.x